How do you know that your distributor is 180 out before trying to start the car?
Short answer: If you are truly at TDC on the #1 cylinder's compression stroke, a distributor installed 180° out will result in the rotor incorrectly pointing to the #6 wire on the cap.
Long answer for anyone needing the info:
Different situations require slightly different processes. The #1 spark plug wire is always at the same location on the cap if you follow the factory service manual and the other wires go CCW for big-block and CW for small-block. Firing order is 1-8-4-3-6-5-7-2 for both big-block and small-block Mopar engines. Factory setup is good for almost all installations.
Not replacing the distributor cap and/or spark plug wires and keeping the factory spark plug wire locations on the cap:
Engine must be at TDC on the #1 cylinder's compression stroke.
Oil pump intermediate shaft/gear installed as per the factory service manual with the slot for the distributor aligned as per manual (Big-block has slot aligned with crankshaft front-to-rear, Small-block has slot "pointing" to the front intake manifold bolt on driver side).
Distributor installed with the rotor correctly pointing at #1 wire/cap location. If the rotor does point to the #1 wire on the cap,
you are good to start. If it is incorrectly pointing at the #6 wire (180° out), remove the distributor, rotate 180° and drop it back in. Re-attach the distributor cap and start the engine.
Changing the distributor cap and/or spark plug wires and choosing the location for #1 spark plug wire on the cap:
Engine must be at TDC on the #1 cylinder's compression stroke.
In this case, you have the option of choosing the location of the the #1 wire and can do so by choosing where to install the oil pump intermediate shaft. The shaft's slot can be placed anywhere that works for your chosen #1 wire/cap location as long as you have verified that the distributor clears everything and will not have its vacuum advance canister hitting something. The vacuum advance canister needs to have enough clearance to rotate for timing adjustment. If you do not have a vacuum advance canister, no issues for clearance.
Just make sure the rotor points to that chosen #1 wire when you drop in the distributor, install your spark plug wires in the correct order, and route the wires to the correct cylinders and you are ready to start the engine.